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Some peptides exert effects through signaling in the gut and systemic circulation rather than direct tissue delivery

Keceli G, Gupta A, Sourdon J, Gabr R, Schr M, Dey S, Tocchetti CG, Stuber A, Agrimi J, Zhang Y, Leppo M, Steenbergen C, Lai S, Yanek LR, ORourke B, Gerstenblith G, Bottomley PA, Wang Y, Paolocci N, Weiss RG

318 Molecular biophysics elucidates how specific nutrients influence the post-translational modification of collagen molecules, such as hydroxylation of proline and lysine residues, which is necessary for stable collagen fibril formation

To date, no human clinical trials have been completed, and all published efficacy data come from controlled murine studies using intraperitoneal injection