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But with IQOS returning to the US, starting with the devices going on sale in Austin, Texas in March 2025, Yolonda Richardson, president and chief executive of the Campaign for Tobacco-Free Kids, is concerned that more people will become users of multiple tobacco or nicotine products

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The broad-ranging interventions adopted by several countries are instructive for the United States insofar as they show that it is possible to reduce the size of the illicit tobacco market through the dedication of tobacco-specific enforcement resources, collaboration across jurisdictions, and comprehensive intervention strategies that encompass a variety of regulatory, enforcement, and policy approaches

PZA is primarily metabolized to PA in the liver by amidase