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Despite being approximately 10-fold more resistant to arsenic than their parental cell line, PML/RAR protein was still degraded by As 2 O 3 in these cells, providing further evidence that loss of expression of the oncoprotein does not confer arsenic sensitivity

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N., Engelhart, E

From the gene-phenotype associations, we decided to pursue the Lipe gene, both because its mutation led to a strong phenotype of fundus spot accumulation and because the fundus spot scale was the only screening parameter that allowed us to identify it