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This evolutionary divergence likely underlies the remarkable variability observed in glial cell transcriptomic and proteomic profiles, morphology, and function

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While T4 is exclusively synthesised by the thyroid, dependent on appropriate and controlled glandular stimulation by the pituitary hormone, thyroid-stimulating hormone (TSH), T3 is only partly synthesised there and generated to a much larger extent locally in many other tissues via enzymatic monodeiodination of T4

It also upregulated the expression of multiple antioxidant defense genes (Nrf2, HO-1, TrxR-1 and xCT), playing a key role in bolstering the cells antioxidant mechanisms