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FDA Zepbound Medical Review (Soccio) escalation peak at weeks 16-20 +2.8/+5.1/+4.1 bpm, change over 20 bpm in about 10% of tirz vs 3.35% placebo, Japanese 15 mg abnormal-pulse 23.3% vs 7.1%

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Keio J Med 50:2630 Shizuya H, Birren B, Kim UJ, Mancino V, Slepak T, Tachiiri Y, Simon M (1992) Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector

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