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Additionally, HIF-1 expression is induced by nitric oxide, inflammatory cytokines such as transforming growth factor (TGF-), interleukin 10 (IL-10), tumor necrosis factor 1 (TNF-1), and hormone-like growth factors, such as insulin-like growth factor [37,64,65]

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If you have or have ever had Leber's hereditary optic neuropathy (slow, painless loss of vision, first in one eye and then in the other eye)

Furthermore, interfering with the blood clotting process has been a practical strategy in order to prevent or treat vascular accidents (Levine et al., 2016)