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X., Zhai H., Guan H., Rong X., Li F., Yu J

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Mechanistically, PGD2 released by monocytes and macrophages mediates the neuroprotective effect of HCA2 by resolving inflammation and inhibiting IB kinase (IKK) and NF-B, which are key players in ischemic brain damage

These challenges, notably the extended duration of sample preparation, the potential for incomplete derivatization, and hydrolysis, are inherent drawbacks of this process (Osorio and Pourfarzam, 2010)