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Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome

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The 17 -HSDs are key factors that catalyze the steroid biosynthesis and metabolism in vertebrates ( 17 -HSDs can promote the mutual conversion between the active (17-hydroxy) form and the inactive (17-keto) form of specific steroids in an NADPH-dependent manner and participate in sex hormone metabolism ( CYP450 ). Aromatase is CYP450(19) , the rate-limiting enzyme in estrogen biosynthesis, through interaction with NADPH-cytochrome P450 reductase (CPR) and catalyzes a three-step hydroxylation to convert androgens (androstenedione and testosterone) to estrogen (estrone and estradiol) ( 2 , better than soybean lecithin and egg yolk lecithin, thereby promoting ovarian development

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Col1a1 fl-stop-fl-DTR mice were crossed with Lrat Cre mice, which express Cre in HSCs in the liver, to generate Lrat Col1a1-DTR mice

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Aug 2010;16(4):365-376

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