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Distinguished features of SOD3 include: Contains copper and zinc as cofactors, similar to SOD1 Forms a homotetramer with a high affinity for heparin and other glycosaminoglycans Particularly abundant in blood vessels, lungs, and kidneys Plays a crucial role in protecting the extracellular matrix and cell surfaces Important for vascular health and blood pressure regulation SOD3's extracellular location makes it especially relevant for protecting against oxidative stress in the vascular system, where it helps maintain endothelial function and vascular tone

Sun Q-A, Kirnarsky L, Sherman S, Gladyshev VN (2001) Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

Orgotein was the first Cu,Zn-SOD mimetic drug developed in 1971

Matsui H, Takahashi R