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In psoriatic lesions, both SP and its primary receptorneurokinin-1 receptor (NK1R)are markedly upregulated, a change that closely correlates with disease severity [67]

Mechanistically, the inflammatory response after heart transplantation is mediated by TLR4/TRIF signaling pathway, which facilitates neutrophil migration to coronary endothelial cells, resulting in ferroptosis in the transplant endothelial cells