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SG conducted the literature search and drafted and compiled the manuscript and created the figures

In agreement with these observations, an increase in the reduced form of plasma homocysteine associated with an elevation of the oxidation rate of homocysteine and cysteine (expressed as a decreased ratio of plasma reduced to total aminothiols) was reported in experimental hyperhomocysteinemia (Guttormsen et al, 1993

400,405 An inhibition in mitochondrial fusion, especially caused by the down-regulation of Mfn, is closely related to liver diseases due to an impairment in fatty acid oxidation, the TCA cycle, and glycolysis

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