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The Th cell subgroups mainly consist of Th1, Th2, and Th17 cells, which play an active role in both cellular and humoral immunity by secreting unique cytokines specific to their distinct functions [86]

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However, prolonged exercise (e.g., exceeding 45 min) may induce central fatigue, reduce frontal lobe activity, and increase neural noise, thereby impairing cognitive performance (Arne Dietrich and Audiffren, 2011