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Spritz, 2012)

The HPV-positive cells, particularly SCC47, showed significant elevations in glycolytic intermediates, nucleotide synthesis, nicotinamide metabolism, and antioxidant demand, reflective of their rapid proliferation and increased oxidative stress

FIGURE 8 Atherosclerosis, a chronic inflammatory disease, may be an ideal environment for the high viral replication capabilities of SARS-CoV-2 in human cells, enhancing hyper-inflammation secondary to immune system dysregulation (Figure 9) that leads to adverse outcomes, as shown in patients with cardiovascular risk factors (258, 259)