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ustekinumab in 3/16, 18.8%) and 87.1% of patients in ABS group due to failure of the first-line therapy (infliximab in 33/62, 53.2%

However, this definition is limiting, considering that cellular signaling and control processes are mediated by specific redox pathways, whose activity is not always directly correlated with the overall GSH/GSSG ratio, as implied by the classic definition