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Studies on patients with ischemic stroke suggest that high circulating IGF-I levels are associated with neurological recovery and a better functional outcome [339], probably due to its neuroprotective and pro-angiogenic effects

Second, the relatively small size of the PostNAC RNA-seq cohort may limit statistical power and generalizability, and subtle or heterogeneous tumor cellspecific changes may not have been fully captured by bulk RNA-seq

This could be demonstrated in patients with detectable 10-100% FR expression but not in those with 0% FR expression

We include them as standard because a program without metabolic support is a harder program than it needs to be