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The area under the curve (AUC) values did not change significantly (Table 6)

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The flow rate was set at 5 l/min and the run was carried out using the following solvents: solvent A 98% water and 2% acetonitrile containing 0.1% formic acid (v/v), and solvent B 98% acetonitrile and 2% water containing 0.1% formic acid (v/v)