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The study medication was stored in a study refrigerator and protected from light until 30 min before administration, when it was allowed to come to room temperature, for participant comfort during administration

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Since heme is toxic in excess, it is bound to proteins called heme proteins, which also form heme enzymes

58 to denote essentially the same concept as koku which is induced in a simple experimental situation where the taste of an umami solution is modified by adding a certain substance