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Stevioside enhances mitochondrial bioenergy metabolism by inducing PGC-1 expression, promoting fatty acid oxidation, reducing fat accumulation, and improving insulin sensitivity, thereby contributing to metabolic homeostasis (Park et al., 2022a)

In addition to murine models, larger animals such as rabbit, dog, sheep, and bovine have played an important role as their IVDs are more similar in size and mechanical load to human IVDs, particularly in studies involving biomechanical changes over time and the application of pre-clinical therapies (Alini et al., 2008