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The primary outcome measurements of the study included change in body weight from baseline to week 26

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Due to the high reaction specificity and orthogonality of the CuAAC click reaction, this two-component stapling strategy can incorporate crosslinks with different chemical properties and functionalized modifications through double-click reactions involving two side chains with azido functional groups at the i , i + 4, or i + 7 positions and a dialkynyl linker

Neither compound has published the kind of long-term hard-outcome data (cardiovascular events, mortality) that ultimately defines a metabolic drugs value, because both are too early in development for that