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Nutrients 10:1531

Coordination of pgc-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation

B-12 is naturally found in animal products, so individuals who eat plant-based diets (vegan or vegetarian) may especially benefit from these injections.

Overall, there was a transient increase in serum creatinine observed within 10 days of dosing in 1.8% of Reclast-treated patients versus 0.8% of placebo-treated patients which resolved without specific therapy [see Warnings and Precautions (5.3)]