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RNAi knockdown of suco-1 or elt-3 suppress SKN-1 activation in amdh-1 mutants, phenocopying the EMS mutants and suggesting a causal relationship between these regulators and SKN-1 (fig2c,d)

These observations were consistent with our results, where Klotho administration inhibited FOXO3 phosphorylation and its subsequent ubiquitination and degradation

Severe cases progressing to liver failure may exhibit progressive jaundice, petechiae, ecchymosis, ascites, peritoneal infections, and hepatic encephalopathy