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In a patient-derived xenograft model, administration of 200mg/kg of CB-839 twice a day resulted in 61% tumor growth suppression when compared to untreated control

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Target gene mRNA data were normalized to Gapdh housekeeping gene (Thermo Fisher, Catalogue# Mm99999915_g1) and data was analyzed by CFX Manager software (Bio-Rad

Zinc transporters are regulated through various mechanisms, including activation of transcription, stabilisation of mRNA, modification of protein, trafficking to specific organelles, and transporter degradation