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In preclinical studies , PYC conferred dose-dependent protection against gamma irradiation-induced lung damage in rats by enhancing antioxidant enzyme activity and reducing oxidative stress markers

Exposure to ultraviolet radiation results in generation of excessive amounts of reactive oxygen and nitrogen species within the cells

[18] Besides these early examples, the role of de novo mutations in autism first became evident when DNA microarray technologies reached sufficient resolution to allow the detection of copy number variation (CNV) in the human genome