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Although liver-on-a-chip technology is costly and the chip manufacturing process is complex, it can mimic the complex in vivo liver microenvironment, precisely control chemical gradients and manipulate parameters such as time, so it has broad development prospects in the research field of cell-matrix and cell-cell interactions

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Moreover, a well-known ferroptosis inducer, erastin, can be loaded into exosomes labeled with folate and delivered to cancer cells that express the folate receptor to generate ROS and glutathione depletion (Yu et al., 2019)

Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: experiences and findings