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10.1126/scitranslmed.3004404 Sci Transl Med

OX40L expression was reported to be induced by exposure of mouse MCs to stimuli, such as toll-like receptor (TLR) agonists and FcRI engagement (24)

Here's what the research suggests for acute situations: The Evidence-Based Natural Stack Quercetin + Vitamin C + Bromelain is often called the "natural histamine support" combination, and there's good reason: Quercetin supports mast cell stabilization and naturally inhibits release of histamine, leukotrienes, and prostaglandins