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(2022)reported that treating a PCOS-IR rat model established by letrozole combined with a high-fat diet with Modified CFD can regulate the NF-B/LCN-2 inflammatory signaling pathway, thereby inhibiting the release of inflammatory factors and upregulating insulin signal-related genes, and ultimately improving the insulin sensitivity of PCOS-IR rats

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Through the disruption of these vital reproductive processes, dysregulation or aberrant exosome activity can lead to infertility (Liu et al., 2024b)

High-throughput screening has identified more potent and specific agents that antagonize the drug efflux activity of MRP1, but these have not yet been widely tested in humans (Boumendjel et al, 2005