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Pediatr Res

doi: 10.1016/j.physbeh.2015.11.009

have revealed that in MDSCs derived from hepatocellular carcinoma patients, hypoxia activates HIF-1, leading to the upregulation of ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) expression, which subsequently facilitates the enzymatic hydrolysis of extracellular ATP into 5-AMP