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Their mechanism is completely independent of the HPTA

Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice

In LPS-stimulated BV-2 microglial cells, ISA can activate the GSK-3 and its downstream Nrf2 and HO-1, which suppressed the activation of NF-B and the subsequent production of inflammatory mediators, causing the inhibition of inflammation (Wang et al., 2018a)