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The current 4-week-per-dose-level schedule was specifically designed to minimize GI side effects while reaching therapeutic doses in a reasonable timeframe

coli found to contribute to HOCl resistance was HypT (hypochlorite-responsive transcription factor, formerly known as YjiE) [270, 271]

Second, the study introduces an optimal control strategy aimed at regulating M2 macrophage activity using advanced mathematical techniques such as Pontryagins minimum principle and Riccati equations, specifically designed to prevent fibrosis