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Description

Efficacy-wise, AOD-9604 produces modest results (2-3 kg over 12 weeks in trials) compared to GLP-1 agonists dramatic weight loss

Allow 2-4 weeks to assess tolerance before increasing

Nuclear NAD + is generated by nuclear NMNAT1 and is largely utilized by PARPs for DNA damage response and nuclear sirtuins such as SIRT1, SIRT6 or SIRT7 for epigenetic deacetylation 82,86

MTHFR deficiencies lead to a shortage of the active form of folate within the body and negatively impacts the conversion of homocysteine to methionine