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Because the process for requesting or granting an ECE will remain the same as the current ECE process, these updates will not affect burden associated with the submission of the ECE form

The ability to interpret and respond appropriately to environmental signals, including cellular metabolic conditions, is crucial in determining the status of T cells and allowing them to adapt to their surroundings

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Among these, a few stand out, notably Quin et al., mRNA-based therapeutics: powerful and versatile tools to combat diseases, and Lu et al., Current landscape of mRNA technologies and delivery systems for new modality therapeutics. The proposed review article, titled Beginning of a New Era of Synthetic Messenger RNA (mRNA) Therapeutics: Comprehensive Insights on mRNA Drug Design, Development, and Applications, is uniquely distinguished from the aforementioned reviews due to its explicit focus on current therapeutic and commercial applications, analyzed through published patents and clinical trial records