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These effects were amplified by selective erythropoiesis activation and inhibited by the ferroptosis inhibitor liproxstatin-1, indicating that Jak2VF signaling accelerates AS by promoting macrophage ferroptosis and erythrocyte phagocytosis (Liu W

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The 1-Cys Prxs contain the redox-sensitive cysteine without a corresponding resolving cysteine

Consequently, regarding the formation of multidrug resistance in tumor cells, besides acting as a detoxification enzyme though excretion of drugs to decrease pharmacological efficacy, GST can also act as an MAPK-pathway inhibitor to improve tumor-cell survival