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and, c) using the set of mutagenic oligonucleotides to generate a set of T cell receptor (TCR)-encoding variant nucleic acids encoding a range of amino acid variations at each amino acid codon that was mutagenized, thereby producing a library of nucleic acids encoding a plurality of variant T cell receptors (TCRs)

Then, they are given once a week for 4-8 weeks

Kim WJ Polymers in Small-Interfering RNA Delivery