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Fans of the Wolverine stack believe that using both together covers more ground than either one alone

2021;23(Suppl 3):5-29

For example, the compound 13 (racemic) is a very week IRAP inhibitor (Lukaszuk et al., 2011) and compound 14 with a 4-hydroxydiphenylmethane scaffold as a substitute for Tyr 2 is essentially inactive (Figure 4) (Andersson et al., 2008)