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This could be interpreted by the structural restriction of peptide chains after molecular aggregation, which necessitated a higher radiation energy to induce the bond vibration

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Another meta-analysis of 9 randomized controlled trials (RCTs) with 486 patients who compared the vitamin E group with the control group showed a beneficial effect of vitamin E on the incidence and symptoms of CIPN but also proposed that routine prophylactic use of vitamin E is still not recommended [78]